Ok, i've got to speak up here. In defense of the N64 controller, as many have stated before; you are not expected to have 3 hands to play it, it gives you 3 options for how to hold it, depending on the game you're playing... and speaking of, did anyone fiddle with the controller options for Goldeneye and find the control style that had you holding 2 controllers? Hands down (sorry bad pun) the best control style for 1 or 2 player modes- left analogue move, right look; left trigger aim, right fire. The only difficult part was sometimes swapping weapons with either a or b buttons, but if you had to swap weapons in a firefight in single player you suck and didn't plan ahead, and who changes weapons multiplayer?!? one shot kills with pistols was the ONLY way to go.
Now Joe, you think you had problems with fighting games and shoulder cramp? Killer Instinct Gold on ludicrous speed *shudder* my thumbs break out in blisters just looking at the cartridge these days.... cut the thumbs off leather gloves and wore them(just the thumbs) while we were playing, and soaked our bleeding stumps in our scotches while we waited for a turn..
ahh the nostalgia...
*EDIT* Yes I owned Mario Party, No none of them still work...
Ah,that's right, back on topic!
The worst would have to be the Sega Megadrive II(i guess that would be the genesis for the yanks?) controller -the one with the extra 3 buttons). 3 words:
Slippery. As. Fuck.