I'm gonna go ahead and say Family Guy.
Now, I really don't like the show, but it's easy enough to avoid so I just don't watch it. But the sheer amount of quotes that come spouting out of the mouths of the fans (the ones I meet anyway) is enough to make me feel that the show is positively poisonous.
They slowly cycle through dull little scenes which work up to an either obvious or completely arbitary 'punchline', and are constantly surprised that I don't laugh, despite me telling them I don't like the show, find it funny, and their monotonous readings of it are even worse.
And these are people who grew up on classic Simpsons!
Again, like it or not, I'm not bothered by your position on Family Guy. I think it's a shit show, and have reasons, debating is fun and I don't mind if people want to argue on why they like it and I don't, sounds interesting. But to shove it so incessantly down people's earholes is plain cruel, and worse, makes you a bore.
Also, I kid you not, someone I know said it was "the most intelligent show ever."
Fuck me, I nearly died of laughter then.