im realy not sure why some people think this is a bad idea.
in only a tiny percentage of all PC's ( that are abel to run witcher 2 ) use FAT32. and those who choice for FAT32, should understand howto make a NTFS partition.
also, why is a 9 gig file a bad idea? just becaus humans can't look in it, doesen't mean your computer has to load or search thruw 9 gigabyte. no, it can simply look where it needs to look. all in all, it would probaly increase your reading speed by not having to search different files or sectors. and as someone mentioned, 1 file ( normaly/usualy ) doesen't defragment.
in general if you hava a HDD of over 10 Gig ( and you need more for the witcher ) then it supports NTFS. and if your 1 of those people who install it on a usb-stick. whell, then your just asking for trouble anyway.
so, is it wrong they left that tiny, insignificant portion that you need a file system that supports upto 9 gigabyte. no, i don't think it is. just like they don't put on the cover that you need to be abel to start up your computer in order to play.
( yes, there are people who don't know how to start up a PC, even if they work with it daily )
oh, and that 0.001% of people that might not be abel to play from it, whell they can easily google the answer now.