Mass Effect (especially "Main Theme" and "Vigil" from ME1, "The Normandy Reborn" from ME2 and "A Future for the Krogan", "Stand Strong, Stand Together", "I was lost without you", "The Fleets Arrive", "We Face Our Enemy Together" and "An End Once And For All" from ME3)
Star Wars (in most incarnations, anyway. Special mention goes to TIE Fighter, where they took the Imperial March and made it sound awesome and heroic and SW:TOR, where they took pre-existing leitmotifs, rewrote them into musical themes for all of the player classes and play it everytime your character does something awesome)
and various other, examples:
Hello Zepp (Saw)
Still Alive/Want you gone (Portal and Portal 2, respectively)
Born To Darkness, Part I (Interview With The Vampire)
Fire and Regeneration (Heroes)
City of Night (Cyberpunk 2077)
The Medaillon Calls/Will and Elizabeth/Barbossa is Hungry (Pirates of the Caribbean)
Ezio's Family (Assassin's Creed II)
Star Wars (in most incarnations, anyway. Special mention goes to TIE Fighter, where they took the Imperial March and made it sound awesome and heroic and SW:TOR, where they took pre-existing leitmotifs, rewrote them into musical themes for all of the player classes and play it everytime your character does something awesome)
and various other, examples:
Hello Zepp (Saw)
Still Alive/Want you gone (Portal and Portal 2, respectively)
Born To Darkness, Part I (Interview With The Vampire)
Fire and Regeneration (Heroes)
City of Night (Cyberpunk 2077)
The Medaillon Calls/Will and Elizabeth/Barbossa is Hungry (Pirates of the Caribbean)
Ezio's Family (Assassin's Creed II)