Your worst Oh Shit, RUN! moment...

[Lelouch vi Brittania]

I gotta say for me it was in devil may cry 1 after you beat phantom (the lava spider/scorpion thing) you go out into the corridor and he appears again but there is nowhere to go you either fight in a space with no room to dodge or you leg it down the hall "HOLY SHIT, RUN!!!

 

[iLikeHippos]

The first time me and my brother were playing left 4 dead and we tried kill a witch / we started to hear the tank song.

We both started to freak out at those points.
"FUCKING RUN BRO! RUN RUN RUUUUUN"

 

[Reep]

My first big Daddy after i shot it once, and in GTA4, when i shot down a police attack chopper, and it ended up bursting in flames and rapidly span uncontrollably towards me.

 

[ObsessiveSketch]

When I realize that I, through carelessness or complete bad luck, have startled the witch.

 

[mrhappyface]

I remember one time, in Red Faction Guerrilla, I thought it would be a good idea to get out of the truck during the sequences where you had to knock down the sensor modules. 30+ Cars ran me over.

 

[Reaper69lol]

Left 4 dead, expert, tank spawned pretty much around the corner....

 

[radio1314]

When playing bad company 2 and seeing a Tank (or two) turn the corner. While your a medic...

 

[T-Blade]

In TF2, I was a lonely scout just running to a capture point, THEN ALL OF A SUDDEN! The whole of the other team Heavy rushed and gangbanged me from all points of entry ):.

 

[Michael Dagastino]

Some one has already said this, but i will say it anyway:

Left for dead 2 on expert. Normally on easy, normal, or hard i run towards with an axe as if i have a death-wish, mostly because i know that i will survive, even if just barely. On expert however, i might as well be a squirrel fighting a bus full of explosives. It's just better to run, and those who fall behind stay behind (That's how we lost Phat Cougar RIP you temporary distraction)

Edit: Several people have already beat me to this.

 

[Brad Shepard]

There was this time i was fast traveling in fallout 3, i warped right in the middle of a battle of the Antaganizer vs a pack of Deathclaws (Dont ask me how it happened) the deathclaws won and i just halled ass. and hey, free quest done.

 

[Music Mole]

When playing Motorstorm 2 I was driving a bike on mud and a monster truck was behind me, inching closer and closer, until it finally crushed me.

I flashed back to when I was watching Ace Ventura 2.

Also, every nightmare in Silent Hill: Shattered Memories, 'nuff said.

"Hey, from the consulate right? This is weird!"
"He wants to go off road"

 

[Rath709]

I have emptied entire goddamned clips into them just to make sure they are 100% dead. The mere sound of them has me running.

 

[The Jono]

Playing Bioshock with a friend. We accidentally hit a big daddy we could ill afford to fight, so after a brief whirlwind of gunfire, explosions and "Oh shit!", we ran out into an open area to recoup and escape, at which point:
"Oh SHIT! There's TWO OF THEM!"

When in L4D all pretence had been abandoned and the group had dissolved. Two AIs were stuck in a room surrounded by zombies, I'd died and my good friend had decided to leg it. It was in the sewers on No Mercy, so imagine his surprise when he saw a tank in the dark. He ran down a thin tunnel and it got stuck. Later on the same game, we were badly mauled and clambering out of the sewers. My friend stuck his head out of the sewer and weas promptly swarmed by zombies. We found that, provided he stayed on the ladder, they couldn't get down but they could hit him. Eventually he was beaten into submission and a STREAM of zombies flew out of the entrance. Like, you couldn't see the ladder for zombies.

On Gears of War we were in the arboretum and my friend said "I know this game. Something big'll come through that wall there". A beserker promptly smashed through a door to the right of it. After some buggering about, we got on the other side of the wall and sighed collectively. Then the beserker smashed right through our side of the wall and was greeted by a hail of lead and bad language.

We survived all these, by the way.

 

[Siberian Relic]

A long time ago when the game was good, I have fond memories of jumping back into Star Wars Galaxies and picking up with my character where I left off: with him safely inside the campsite. Then the game loads and I find my camp gone and my character completely surrounded by red level enemies.

Shadows of the Empire. Turning the corner and coming face-to-face with a Wampa.

 

[Lancer723]

Someone already mentioned it, but the bear in Condemned 2 was the biggest OH SHIT RUN FAST NOW moment I've ever had, followed by lots of screaming and my untimely death.

Also, L4D and L4D2 expert campaigns when the tank suddenly appears from around a corner and bats one of teammates at me.

 

[Cody211282]

Running into a Thresher Maw on foot in Mass effect, and that was the first planet I went to after the Citadel.

 

[CD repo man]

Last night, i accidentally jumped on top of a tank's head in L4D2. i managed to get away without getting hit, too, which made it one of the more awesome tank fights i encountered.

 

[joschen]

<img src="http://images4.wikia.nocookie.net/__cb20080802180453/wowwiki/images/9/98/FelReaverGoesVroom.jpg" height=340

Haaaaaaave you met Fel Reaver?

 

[Xorghul]

That would have to be in Nosferatu when the dogs chase you. Admittedly, I was only eight at the time, but still, scared the shit out of me.

 

[jboking]

Playing fallout 3. I was just kind of roaming the wastes but noticed I was getting low on some of my special ammo(shotgun shells, sniper rounds, anything other than 10mm) and Evergreen Mills was nearby. I had already been there and wiped the place out, but I left the Super Mutant Behemoth in his cage cause I wasn't strong enough to take him out yet and I had loot to sell. I decide to drop by and visit to collect more ammo I may have missed. Some Raiders had respawn(or I just missed them) and a small firefight ensues. Nothing too big to handle. I get ready to finish off the last enemy by throwing a grenade. The raider was standing next to the behemoth cage. The explosion from my grenade crippled the generator. Behemoth cage opens. I still don't have a significant amount of ammo. No mini nukes either.

[HEADING=2]RUN FOR THE HILLS!![/HEADING]