Been watching clips of House lately and I remember really enjoying it during its run, even though I didn't get much chance to watch beyond season 4 with much regularity (still think it's good, but not my favourite, but might be if I ever get to watch it all). So, aside from anime:
Yes, Minister (& by association, Yes, Prime Minister) - Nigel Hawthorne was brilliant in this series and the dynamic among the main cast was superb, and the one classic British comedy I actively encouraged my old man to buy.
Scrubs - loved this show and still do, great balance of character driven development and slice-of-life (apart from S9).
Futurama - I basically nicked my sister's copy of the DVD boxsets, she was pissy I watched them more than she did.
Dollhouse - took a bit to get going, liked the premise, wasted potential, but I still enjoyed it enough to rate it alongside Firefly
Castle - 'cos Nathan Fillion doing Nathan Fillion things means I'm easy to please
Honourable mentions (because they're panel shows):
Call My Bluff (Sandi Toksvig and Alan Coren... in the same studio... what's not to love)
QI ('cos Stephen Fry)