Deadspace 2 (bought)
Dawn of War 2 Retribution (preordered)
Dragon Age 2 (preordered)
Shogun Total War 2 (preordered)
Sims Medieval (curious, preordered)
Two Worlds 2 (waiting for reviews)
Witcher 2 (preordered CE like the fist of the north star)
Earthrise (fantastic MMO, bought)
TERA Online (day one purchase)
Guild Wars 2 (waiting for CE, will preorder like fist of north star double)
Mass Effect 3 (waiting for CE)
Above are the ones I wouldn't go without no matter what. This year is looking pretty expensive, but so much better than 2010, which was pretty barren except for ME2 (If you avoid Obsidian like the plague it was).
Also, it's the year of the PC baby. There's a tonne of exclusives I haven't listed which I may yet buy. Can't wait.