2019-2020 coronavirus pandemic (Vaccination 2021 Edition)
- Thread starter McElroy
- Start date
Yes. Who'd have thought that letting dozens of people congregate indoors might help spread infection? But someone's got to get into the city centres to save Pret a Porter.
We've got students saying "Help, how do we do face to face teaching when we can't have more than 6 people meet" because evidently their reading comprehension does not extend to noticing that work and education are exempted. I find it bizarre that a bunch of students training to be medical doctors are so panicky about potential exposure to infection. Doesn't bode well for their career prospects.
For once good news
https://www.spektrum.de/news/langze...1766281?utm_source=pocket-newtab-global-de-DE
It seems that covids long term damages might not actually as permanent as assumed. A lot of people who still showed severe lung damage after 6 weeks according to CT scans have eventually improved their condition after 12 weeks . Study is still ongoing with additional scans planned after 24 weeks.
https://www.spektrum.de/news/langze...1766281?utm_source=pocket-newtab-global-de-DE
It seems that covids long term damages might not actually as permanent as assumed. A lot of people who still showed severe lung damage after 6 weeks according to CT scans have eventually improved their condition after 12 weeks . Study is still ongoing with additional scans planned after 24 weeks.
USA
The worry though is that even though we have some improvement, we are still expecting the long term effects that we experienced with MERS and SARS, which regretfully found that in our 10 year+ studies, leads to pulmonary fibrosis. But on a larger scale and bilaterally rather than unilaterally, as COVID-19 attacks both lungs (bilaterally) and SARS and MERS were more unilateral in their attacks, but is the same type of damage.
We expected the improvements we are seeing now as that is pretty much the same we saw in SARS and MERS patients as well experiencing similar damage. Usually after 2 years it shows improvement, but then the long term studies show pulmonary fibrosis anyhow. It is the results of the 10 and 15 yr SARS and MERS studies that worry us.
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There's been pretty constant good news. We started with a virus that could have potentially infected 70% of everyone and killed 5% of those, and have had lists of good news ever since.
This is exactly what we expected to happen however, when compared to our SARS and MERS studies, so it isn't actually changing our outlook for 10 and 15 yrs due to the 2yr results being promising as well. There was improvement up to two years after recovery, but that did not change the outlook of developing pulmonary fibrosis longer term. Unless we find new methods and change how we treat COVID-19 patients vs the SARS patients long term, we can expect same/ similar results in COVID-19 Patients as we had in SARS 15 years down the road. The claim " long term damage reversible" is misleading. Only some of the damage is reversible.
"We confirmed the binding of SARS-CoV-2 and ACE2 by bioinformatic analysis. TMPRSS2, ADAM17, tissue inhibitor of metalloproteinase (TIMP)3, angiotensinogen (AGT), transformation growth factor beta (TGFB1), connective tissue growth factor (CTGF), vascular endothelial growth factor (VEGF) A and fibronectin (FN) were interacted with ACE2, and the mRNA and protein of these molecules were expressed in lung epithelial cells. SARS-CoV-2 infection increased ACE2, TGFB1, CTGF and FN1 mRNA that were drivers of lung fibrosis. These changes were also found in lung tissues from lung fibrosis patients.
Conclusions
Therefore, SARS-CoV-2 binds with ACE2 and activates fibrosis-related genes and processes to induce lung fibrosis."
"The most severe sequela of pathogenic coronavirus infection-induced SARS is lung fibrosis that up to 45% of SARS patients develop lunf fibrosis after 3–6 months, and this potentially sets an important context for COVID-19 [4,5,6,7]. Lung fibrosis is characterised by excessive deposition of extracellular matrix (ECM) proteins, such as fibronectin (Fn). This results in impaired lung function and reduced gas exchange. Transforming growth factor beta (TGF-β) associated signalling pathway play important roles in lung fibrosis, but the role of this pathway in COVID-19 is unclear. A recent study shows that COVID-19 patients have a high risk of lung fibrosis [8]. Increasing studies show that COVID-19-induced acute respiratory distress syndrome (ARDS) results in diffused alveolar damages in lungs, and the cases of long-term ARDS leading to lung fibrosis are starting to be reported [9,10,11,12,13]. However, the links between SARS-CoV-2 and lung fibrosis remains unclear.
SARS-CoV and SARS-CoV-2 share approximately 76% amino acid sequence homology that lead to the similarities in their biological properties [14]. The spike (S) protein is a key structural component of CoV that binds to host cellular receptors that facilitates viral entry into target cells [15]. Angiotensin-converting enzyme 2 (ACE2) has been identified as a receptor of SARS-CoV-2 [4], which is cleaved by type II transmembrane serine protease (TMPRSS2) to augment virus entry into host cells [15]. ACE2 is also cleaved by a disintegrin and metallopeptidase domain (ADAM)17 of the host, which facilitates shedding of ACE2 into the extracellular space to bind with CoV [16]. However, it remains unclear how SARS-CoV-2 infection induces lung fibrosis."
SARS-CoV-2 induces transcriptional signatures in human lung epithelial cells that promote lung fibrosis - Respiratory Research
Background Severe acute respiratory syndrome (SARS)-CoV-2-induced coronavirus disease-2019 (COVID-19) is a pandemic disease that affects > 2.8 million people worldwide, with numbers increasing dramatically daily. However, there is no specific treatment for COVID-19 and much remains unknown about...
respiratory-research.biomedcentral.com
Novel coronavirus (COVID-19) imaging features overlap with SARS and MERS
Although COVID-19's imaging features are variable and nonspecific, the findings thus far do show ''significant overlap'' with those of severe acute respiratory syndrome and Middle East respiratory syndrome. The early evidence suggests that initial chest imaging will show abnormality in at least...
www.sciencedaily.com
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A bit like the blitz in WW2 was constant good news for the British, I guess. The government had projected German bombing to kill half a million people within the first month; as it happened over a year they "merely" killed under 50k and destroyed 2 million homes.
Good news! It turns out the coronavirus is less deadly than the Black Death!
Sure, if you're not in the US or some other country that royally screwed this up!
We actually initially thought however, it would be like SARS, but then it was like SARS BUT was much more contagious than SARS, attacked the vascular system unlike SARS, did bilateral damage rather than Unilateral damage to your lungs like SARS, and Our government didn't even attempt to contain or control it like they were able to do with SARS so sure, if we put aside all that then it has been great news! XD
Unless you were one of the 180,000+ Americans or their families that died, then it is a bit more difficult to ignore.. Wasn't it like 60k deaths Trump predicted due to his exceptional handling of the invading " Chinese virus"?
See, the fact that it's projected to kill 300,000 people in the US before the end of the year is actually great news. Now all those dead people won't be filing for unemployment, and that will mean the unemployment numbers will go down on paper. Everybody wins!
Right because Trump's planned " K recovery" would have just put more of those people on the bottom half of the K that Trump isn't going to do anything to help at all once he is reelected! He is only willing to do anything at all to barely help them because he is worried about losing votes, but once he can't be elected anymore, he doesn't even have to bother with that!
Yeah, it's still sitting at a 3% US mortality rate along with the rest of the kleptocratic shithole world, and I'd wait until more definitive studies are released about the long-term health impacts of COVID infection come out before jerkin' your gherkin to that.
If the US screwed it up, it's only by overreaction. The next time you get actual bad news about this pandemic, it's going to be the retrospective studies of how much death could have been avoided by not freaking out.
DO you live in some alternate reality where the countries that actually took proper precautions, provided their first responders with adequate PPE and the populace behaved responsibly to reduce the spread somehow did worse than the US? That was the APPROPRIATE reaction. The US failed at that on every level due to a president pretending it was a hoax, acting too little too late and then not following through where needed.
The ENTIRE world sees this, but you don't? Hmm. Okay.
The US half-assed the shutdown due to lack of leadership from the central government and poor compliance among the poorly educated populace.
The US Failed to provide adequate PPE to first responders and the general public.
Misinformation spread by the president himself lead to increased ignorance and lack of compliance among the populace resulting in numerous unnecessary deaths and infection spread that could have otherwise been prevented.
It is truly astounding that some people have actually convinced themselves that the US did too much to address this rather than accept the reality that the ENTIRE world sees that the US royally screwed up by not doing enough.
That is the point here, the President should not have freaked out, he should have actually lead his nation through the crisis appropriately to minimize the spread of infection and reduce the death toll by providing those on the front lines the appropriate equipment they requested to combat the virus, the general public the appropriate supplies needed to protect themselves and reduce the spread, and made the people his first priory so that the nation could have made it through this with the fewest causalities in a calm and organized manner. Instead, the President of the United States chose to be irrational, chaotic and incompetent at every level making it worse for everyone, increasing the death toll and spreading ignorance and misinformation.
If the US had just done a proper shut down in the first place and mask mandate , it would have taken less time, less people would have died from both the virus and the complications from the shutdown itself, businesses would have bounced back faster, and we would all be in a better position right now. We didn't do that and now it is what it is.
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I know very little of the good news stemmed from the efforts of the US federal government.
Okay exactly what part of "novel, highly contagious, virus with no data on long-term resistance or immunity, or long-term health consequences" do you not understand?
Let's put this another way. There's a wall with a waist-high hole in it. You have no idea what's on the other side of that hole; could be a hot big-titty blonde that could suck-start a leaf blower, could be a salad shooter. Now, you could either take a step back and look through the hole first, maybe put an exploratory finger in, or you could just yeet your johnson in balls-deep on the first go.
What you're saying is roughly equivalent to "yeah I went for it, but the good news is there was only a taser on the other side, not a cheese grater!".
Depends who's got it to be honest. Some people are rubbish.
This is probably the least deadly pandemic ever. Also, the cure is literally just Vitamin D!!!
The mortality rate is not at 3% nor has ever been at 3%. The current numbers put the mortality rate at anywhere from 0.22-0.67%. Way back in April, anti-body surveys put the estimated death rate at 0.37%, which is right in line with what current numbers put it at. Thus, it was never even at 1%, yet alone 3% or 5+% either. Plus, the mortality rate and hospitalization rate is dropping considerably now as well.
The US did a shit job, but we also did overreact. Do you not recall all the ridiculous stuff people were wearing in the 1st month or so of the pandemic? A former friend said there was going to be martial law enacted (and I'm like the only Martial Law you'll see is Sammo Hung and Arsenio Hall). My aunt and uncle were taking out thousands of dollars weekly from the bank and every time they'd come back from the store, they were disinfecting everything (the groceries, car, etc.). There was a major shutdown for really no reason when all you had to do was wear masks and not congregate publicly in indoor spaces, that's literally Japan's strategy and who's doing better at this pandemic, US or Japan? You didn't need to be South Korea or Taiwan to handle the pandemic well. More hardship is most likely going to happen due to the economy shutting down than the pandemic will cause directly.
There is data on long-term resistance and immunity. We discovered that SARS-COV-1 has at least 17 years immunity because we found out that people that had it 17 years ago are immune to SARS-COV-2 today. All signs point to long-term immunity and this virus will be gone for good rather soon. COVID-19 is not going to be something that comes along every year, this is not the "new normal".