All the characters in Lost were really good at navigating on the island.
A big part of Left 4 Dead is going back for your teammates before they die.
Half Life doesn't use a lives system, and you can't have half of one even if it did.
Silent Hill is pretty flat all things considered.
The Witcher fights demons more then witches.
In Prototype you're something like the second or third iteration of the virus, not the first.
Everything, the Blight, the social problems, the mage/Templar conflict, was already well established by the beginning of Dragon Age. It wasn't the Origins of anything.