Despite being extremely controversial, if ME3 got anything right, it was the soundtrack. Every song is epic in its own right.
Honorable mention goes to Deadly Premonition - incredible, AWESOME use of saxaphone to add a horror element. if 'Amazing Grace' had been acapella throughout instead of adding the organ, it might've been my favorite track ever in a game. Really haunting, especially in the context of playing as the Raincoat Killer.
The Phoenix Wright series is also incredibly well done. Especially 'Gyakuten Saiban meets Orchestra' - go listen to Godot's theme and tell me you don't feel like a classy black-and-white movie detective.