Are there any video game with a female as the MAIN villain ?

[Extragorey]

Unreal Tournament 3, Portal, Portal 2 (arguably), The DIG (the giant spider), and Pokemon Crystal (the redhead... maybe subjective).

That's about all the games I can think of off the top of my head.

 

[Hristo Petrov]

Ultima 2: Revenge of the enchantress

 

[SenorPablo]

battletoads

 

[northeast rower]

Bioshock 2 did, but other than that Uncharted 3 looks like it has Supernanny as the final boss.

 

[sooperman]

Catherine.

OT: I hear that the antagonist of inFamous 2 is going to be a woman.

 

[Sexy Devil]

Arguably the Witcher 2.

Spoiler

Letho just kinda stops being a huge enemy towards the end in favour of Sile, Philipa and Saskia. And even if she was being screwed with, I'm still counting Saskia.

Plenty of female antagonists in Deus Ex: Human Revolution too.

 

[Shakomaru]

ANY game that has the word Banjo and/or Kazooie in the title

 

[Zeraiya]

Actually, Jaqueline Natla from the Tomb Raider series. Amanda was also basically the main villian of Tomb Raider: Legend as well.

Also, the Red Queen in Alice. (not Madness Returns)

 

[MeatsOfEvil]

Star Wars: Bounty Hunter

 

[Shakomaru]

Unreal Tournament 3, Portal, Portal 2 (arguably), The DIG (the giant spider), and Pokemon Crystal (the redhead... maybe subjective).

That's about all the games I can think of off the top of my head.

What Redhead? Silver's a dude...

 

[Gerwich]

The entire Breath of Fire series.

 

[razerdoh]

Banjo & Kazooie...

 

[DannyJBeckett]

Dead Space
Sly 2: Band of Thieves
Spyro 3: Year of the Dragon
Crash of the Titans
Destroy all Humans!
Grand Theft Auto III
Jak & Daxter: The Precursor Legacy (Male & Female dual-villains)
Bioshock 2
Portal (Technically)

Aaand that's all I can think of.

 

[inFAMOUSCowZ]

You have the locust Queen for Gears as a villain, and I guess main villain for Gears 3.

 

[WarpZone]

How is it possible that nobody's mentioned Eve from the original Parasite Eve?

Everything stylish about the sorceresses in Final Fantasy 8, they ripped off from Eve, except Eve was actually MENACING:

http://www.youtube.com/watch?v=D2TYdzkKWdA&playnext=1&list=PL15EA6A6314D6EF59

You youngin's need to learn your history...

 

[Soviet Heavy]

Big Boss in Metal Gear Solid 3: Snake Eater. Though she was more of an Anti-Villain in the end.

 

[mrF00bar]

Jedi Knight: Jedi Accademy had a female antagonist. I can't remember her name though. Talon something... Of course, she did get possessed by Markos Ragnos, so, who knows.

Tavion was her name, she was in Jedi Outcast as well but you don't get to kill her.

 

[Rhaisington]

Just browsed the list so far. Has Nox been mentioned?

 

[Cridhe]

"Mother" Brain?