* John James Audubon, ornithologist (spent several years in Henderson in the 1810s)
* Sam Ball, Former NFL player
* Stephen Bardo, former NBA player
* John J. Becker, composer
* Teddy Darby, blues musician
* John Lloyd Dorsey, Jr., former member, United States House of Representatives
* Joey Goebel, author
* Gregg Hale, film producer, Blair Witch Project
* W.C. Handy, blues legend (spent about a decade in Henderson)
* General Adam "Stovepipe" Johnson, Confederate general during the American Civil War
* Kristen Johnson, former Miss Kentucky USA
* Grandpa Jones, Louis Marshall "Grandpa" Jones, banjo player, comedian, born in Henderson County
* Kasper from the K, rapper
* Husband E. Kimmel, commander of the U.S. Pacific Fleet during the Japanese attack on Pearl Harbor
* Darrell A. Posey, anthropologist, ethnobiologist
* Lazarus W. Powell, former governor of Kentucky
* Ann Rutledge, Abraham Lincoln's first love, was born just outside of Henderson
* Ingram Crockett, poet and journalist
...Yeah.. Yay, we must have success in the fucking water out here.
A banjo picker and a fucking bird watcher.