Painkiller:
A pharmacy simulator, where you must use customer body language and visual clues on perscriptions to determine if they are a legitimate customer needing some Percocet for a surgery, or a doper trying to rip you off and get high off your perscription drug stock.
Duke Nukem Forever:
Duke Nukem, the radioactive villain from the 90's cartoon "Captain Planet and the Planeteers", is caught in a time warp, and must use his nuclear polution powers to toxify the space-time continuium and destroy the alternate plane of existence in order to escape.
Bauldur's Gate:
In this construction simulator, you play as Frank S. Bauldur, professional fence builder, as he constructs elaborate fences and barriers for rich people's mansions to keep out thieves, papparazzi, and stalking exes.