Thanks for all the rules everyone, I've decided on my final ruleset and it's as follows;
-I Can save (In case the game freezes)
-When I'm dead, I'm dead for good
-I can only carry enough ammo for 15 magazines of each type of gun I currently have (E.G. if I'm carrying a 10 mm pistol that gets 10 rounds a magazine, I can only carry 150 10 mmbullets at one point)
-I can only carry three guns at all times, minus ones I use for repairs
-I cannot use any followers
-Must discover all locations in the base map (None from any of the dlcs)
-I cannot exceed 200 pounds of combined weight
-All bobble heads must be collected
-Cannot use Ghoul Mask in any metro
-May only use Ghoul Mask if I decided to go with the option of letting the ghouls in and having them slaughter everything
-All energy weapons and .44 magnum ammo must be looted, the rest can be bought.
-No using anything that increases my AP
-No fast traveling
-No using the Megaton or Tenpenny house
-Only 3 stimpaks can be carried at all times
-No explosives besides the Miss Launcher
-Melee weapons can only be my Fists, Baseball bat, and pool cue
-Can only wear my Vault 101 jumpsuit unless absolutely necessary (I.E. if I do end up play Operation Anchorage)
-Shotguns are off limits
-I cannot use any chems ever
-I can't take any perks that increase DR, or Rad Resistance
-Cannot do the Wasteland Survival Guide
-Megaton, and Tenpenny tower must be 100% cleared of all life
-I can only drink Dirty Water
-Fat man is off limits
-Xuan is off limits
-Miniguns, and Gatling Lasers can not be used
-Stimpaks can only be used to heal concussions
-Rad-X, and Rad Away are off limits
-All other injuries including radiation must be cured by a doctor
-Everything must be dropped after Vault 101 besides my jumpsuit..
-All repairs must be made by me
-Not allowed to use Grim Reapers Sprint, Explored, or any other perk that replenishes, increases, any thing beyond skill points.
-Deathclaw sanctuary must be completed before I go into vault 87..
-Can't use Animal Friend
-No using Intense Training, All SPECIAL stats can only be raised by their respective bobble head
-May only use the standard energy pistol
-If my energy pistol runs out of ammo, I cannot buy or pick up any more, I must sell it or drop it.
-All Behemoths must be killed back to back (With the exception of the Behemoth in the GNR quest)
-If a weapon breaks during a fight, and I have no way to repair it right away it must be dropped
-No traveling at night
I feel that sounds pretty good right there, also I'm playing on the Xbox360 version so I'm afraid I'm going to have to micromanage my ammo. Which wont' be too much of a pain, by only being allowed to carry three weapons (four including my fists) at any given time..
Oh and I can only use the standard energy pistol.