For stats, pick small guns, energy weapons, repair, lockpick, speech, or stealth. Appearance doesnt matter, perks are really all personal preference.
But heres a big one: BUY BROKEN STEEL. IF YOU DONT BUY THIS DLC, YOU WILL BE SEVERELY DISAPPOINTED AT THE END OF THE GAME.
Also, its easier, I think to go through the game on the first try being evil. Thats where stealth comes in handy. Youll get good money from slaving and stealing, and itll just be easier. Being good is harder, but you get Fawkes as an ally, so that makes up for everything. If you go good, get fawkes. No excuses. Youll know when you meet him.
Just a baseline thing tho. For moral choices, exploring, do that on your own. You get no advice from me there. Its personally my favorite game, and you really need to do it on your own for the full experience.