If you're having trouble then you'll want to start completing more side quests. Also, while it doesn't make a huge difference, get some combat armour. Also increase your repair skill so you can repair your own weapons (most importantly the hunting rifle and the assault rifle, you'll find them on super mutants everywhere). I also suggest being evil on your first run through so it's easy to get money and items. If you didn't blow up Megaton then go get Jericho to follow you for 100 caps to make that easier and find Dogmeat. Companions really help a lot.
If you need any help with quests and finding unique weapons (they help a lot, much better than the ordinary version) check out the Fallout wikia.
http://fallout.wikia.com/wiki/Fallout_Wiki
That has everything you need to know and more. After all that, you're on your own.
If you need any help with quests and finding unique weapons (they help a lot, much better than the ordinary version) check out the Fallout wikia.
http://fallout.wikia.com/wiki/Fallout_Wiki
That has everything you need to know and more. After all that, you're on your own.