Why do people think that Fallout MUST BE STRICTLY AMERICAN, otherwise the humour, charm and purpose will be lost!! Why? Who said anyone outside of the US got the humour as it is now? And how many outside the US understand the relevance of the American dream? And wouldn't the comedy and charm be replaced with a different country's comedy and charm? If we can relate to the US charm, are you saying that the US cannot relate to anyone else's charm? Fable had some British humour and twist, that game is popular, so I don't quite see why a Fallout elsewhere wouldn't be.
And who said everything would be lost, having a fallout elsewhere isn't stopping the series going on, technically its a spin off, so its okay to change everything to suit the locale, its not as if I as a gamer particularly care whether the deathclaws and super mutants are in it or not, as long as they are replaced with something equally as interesting.
Come off it, its a game, it isn't a religeon, let others experience what US gamers find so unique and interesting about it. I don't know half the places in Fallout 3 but enjoyed it and understood it all the same, are you saying you would be incapable of doing that if it switched country?