Well, it depends. For a longer ranged approach I will usually use the hunting rifle, and if that lacks ammo, the sniper. For general charge in attacks, I will use the Chinese assault rifle, or Sydney's ultra SMG. Generally, I don't use melee, but when I have to, I use the strongest thing in my inventory. Usually a Deathclaw gauntlet. But, for funsies, nothing can beat the power glove for melee.