Hmm, for the literal account of in a video game, I would have to say the Hulk, along with Captain America, and Spider-Man, just for transportation needs. But those characters are more closely related to comic books then video games. But if we were to choose characters who are exclusive to Video Games, I would have to say Sly Cooper, because running around and pressing "Sguare" never fails.
-This-is-Hip-Hop