Pokemnon Blue: I still remember the day I got it. It was raining pretty hard, and we were having a garage sale. It was my birthday. I got it in the middle of the garage sale and drifted off from the real world. I got into a Metapod V. Metapod battle. It was also the same day I got my purple see-through GBC. I'd been a Pokemon fan from the anime, but I've never stopped playing the handheld games. I'm getting X on the 12th.
VTMB: I've used the Malk mindset to pretty much not give a fuck about what people think of me anymore. And if they get on my nerves then so the better.
Timesplitters 3: I can damn near play through this with my eyes closed. I know it almost top to bottom, and I can beat it in around four hours. I know all the tricks, the secrets, and paths.
007 Nightfire: See above, I've always been a shooter fan, but I always prefer analogue sticks to M&K. And I'm proud of it, not to hate on PC gamers, but it's something special to me. Also I own 007 legends and look at it and just think "...wow. what the FUCK happened?" Even though I kind of know it was part time constraint, part Activision, and part probably some key people at Eurocom left in between titles. But wow, that game sucks.
Crash Bandicoot: The first game I ever played EVER. While 3 is my favorite, the series as a whole made a huge impact on my life. Even though I know Andy Gavin is gone, I still snap up every new game ND puts out. And they still stick to the motto of complexity for quality. I spent so much time on CTR too. It just cuts me up inside about what happened. I still laugh at Radical's grave.
GTA 3: First experience with an open world/mature rated game. It blew my mind all the amazing things you could do. You could be on foot, you could drive cars, you could explore, you could run people over! Oh it was fantastic!
EDIT: I suppose Bioshock 1 should get a special mention. There have been fantastic games this generation, Far Cry 3...one of US. Borderlands 2...one of US. Arkham City...one of US. Fallout New Vegas...one of US. Skyrim...one of US. inFamous 2...one of US. GTA V...one of US.
But Bioshock has had the most playthroughs. I freaking love that game, and no matter how many times I play it, I have never found all the audio logs. But yeah, favorite game this gen. EVEN THOUGH I had the twist spoiled.