Dungen Keeper 3, there was even a trailer, bring back Bullfrog.
Full Throttle 2, it also had a trailer.
Freelancer 2
Freespace 3
Omikron Nomad Soul 2
Deus Ex Human Revolution 2, with Adam and his charismatic voice.
Jedi Knight 3, Kyle Katarn for the President!
Max Payne 3, real Max Payne 3, not just a bloody spinoff.
Beneath A Steel Sky 2, it seems it will be done.
Oni 2, make it happen Bungie. It deserves a sequel more than Halo 6, and also I love that atmosphere.
a singleplayer game based on Unreal Tournament cyberpunk-ish level designs.
a sequel to Vampire The Masquerade Bloodlines (a Hunter game perhaps?) with combined efforts of Troika and Obsidian staff.
Beyond Good And Evil 2, release it already.
Undying 2, similar concept in the same world with different character and with the same developers.
A new Planescape 2 game looking very much like Torment 1 atmosphere and developers but not a "Torment 2", and then a Dark Sun game with the same engine.
Mech Commander 3, the previous 2 game were awesome, I want to salvage more Mechs!
System Shock 3: Bioshock series was kinda good, but they sux compared to System Shock series, bring back original series.
Warhammer 40000: Space Marine 2, the story of the first game was very fun.
sequel to Stunts or Need For Speed 2, I want a racing game with supercars, not hard like a simulation, not wacky like action driving games.