There's a number of them,
Dead Space (the first one): Got to the final boss, but after several attempts got fed up with it.
LoZ: Skyward Sword: Got to the first boss, fought him once, haven't gone back. One of the major breaking points for me was the shield degradation thing. Pain in the ass.
Star Trek: Legacy: Got to the one early Next Gen mission where you're supposed to stop these stellar fragments from hitting these planets. No matter what I did I couldn't pull it off.
Persona 3: Got to final boss, fought him 3 times, got fed up. Been thinking about going back and trying the game from the start again though.
Sonic Heroes: Fuck those special stages
Red Dead Redemption: Got bored.
Warcraft III: Not sure why, maybe I should reinstall it and try again.
Destroy All Humans: Got to this one mission where you're supposed to nuke the human made flying saucer, couldn't figure out how to pull it off. Got fed up with it.
Spider-man: Web of Shadows: Got sick of being Luke Cage's *****. IE the plot didn't seem to be going anywhere.
...and many more.
Dead Space (the first one): Got to the final boss, but after several attempts got fed up with it.
LoZ: Skyward Sword: Got to the first boss, fought him once, haven't gone back. One of the major breaking points for me was the shield degradation thing. Pain in the ass.
Star Trek: Legacy: Got to the one early Next Gen mission where you're supposed to stop these stellar fragments from hitting these planets. No matter what I did I couldn't pull it off.
Persona 3: Got to final boss, fought him 3 times, got fed up. Been thinking about going back and trying the game from the start again though.
Sonic Heroes: Fuck those special stages
Red Dead Redemption: Got bored.
Warcraft III: Not sure why, maybe I should reinstall it and try again.
Destroy All Humans: Got to this one mission where you're supposed to nuke the human made flying saucer, couldn't figure out how to pull it off. Got fed up with it.
Spider-man: Web of Shadows: Got sick of being Luke Cage's *****. IE the plot didn't seem to be going anywhere.
...and many more.