Portal an TF2 are definatly very funny. Generally, all Valve games make me laugh. If I had to point out other games I'd say:
-Bard's Tale
-Conkers Bad Fur Day
-GTA Series
-Star Fox (Do a barrel roll!)
-Psychonauts
-Warcraft III
-Zero Wing (All your base are belong to us)
-Banjo Kazooie
There's more than that, but I couldn't think of them.
Kulingile said:
Mass Effect 2 had some good humor.
"I'm sorry, I'm having trouble hearing you. I'm getting a lot of bullshit on this line."
Damn! I forgot about ME2!
"Krogan testicles were going for 10,000 credits a piece, and that's 40,000 for a full set." -Garrus
Then there are funny ones in Mass Effect 1:
"Why do I always get the feeling that when someone says "with all due respect" they really mean "kiss my ass." - Ashley