Hmm... with me it's more like what wouldn't I erase...
Call of Duty, love the earlier games, don't know what went wrong with the latest ones, maybe just Modern Warfare and World at War.
World of Freaking Warcraft
Fallout 3, how can the people who did Oblivion mess it up so much?
Fable, seriously, what is it with that series? Everyone says it's so damned good when it's so bloody boring.
The first Sims' game, you can't boast about having an innovative and unique game when I have to spend most of my time keeping my sims from: starving to death, going into clinical depression, getting fired from work, or pissing themselves.
Runners-Up:
Black and White: Disqualified for the fact that it has its charm and parts of it can be outstandingly hilarious (who doesn't laugh at the fact that you can improve the productivity of your farmland by having your giant creature avatar take a dump on it?)
Halo: Disqualified because I actually had fun playing it, I just hated the story and the fact that it always gets presented as something new and innovative for ripping off everything that was once new and innovative.