These characters don't really look any realer than those in Dead Rising or Prototype, and I personally don't think they're realistic enough to invoke Uncanny Valley. Usually Uncanny Valley happens for me when the characters are motion captured, because then they move realistically. These characters don't really seem to do that.
My favorite part of the trailer is the first time Jason goes missing, and as the Dad-guy is running around, he pushes into the mall crowd. A woman walks into him and stops, but the walking animation keeps going, and then she levitates up a bit and bounces around him. I never even saw this in Prototype - this is more of a Fallout 3 blunder, and as we all know, that game had many, many strengths, but the character animations and collision physics were not amongst them.