Okay. So. I'll start with my first run (I did the mission twice because I couldn't go into ME3 with a dead Garrus, that's just not right).
I had all of the upgrades for the Normandy, so I took out the Collector Ship with minimal damage and no casualties. I had Legion go into the vents for me, and took Garrus and Tali with me. Miranda led the fire team, and I had no casualties. So far, so good. When I met with me crew, I had Grunt escort them back. I figured he'd be a good bodyguard. He was. I had Jack (Who wasn't loyal due to my siding against her in her spat with Miranda) do the Biotic Barrier, and once again brought Garrus and Tali. I got through that part swimmingly... UNTIL Jack decided, "Fuck this, I'm done," and dropped the barrier before Garrus was safe. He was stung by robotic Africanized killer bees and carted off to be Reaper food. So, I gave my speech and took Mordin and Tali into the final battle with the Shambling Were-Jesus. Everyone lived, except for Jack who I happily watched be trampled by the Collectors. And then I remembered that my favorite squadmate from ME1 and ME2 was dead, and I reloaded my save.
Only thing I did different was that I had Samara do the Barrier. Jack still died, but I don't care. I actually set out, from when I saw her debut trailer, to kill her off. I didn't want her on my ship.
EDIT: Oh, and I blew that fucker right out to Saskatchewan when I got the chance. Mostly because I knew that the Illusive Man would simply use it to make the all the other races bow down to the supreme Overlord that is the Human Race, and partly because I hadn't blown up an entire map since Virmire.
