The "Synthesis" ending seemed like it tore open another giant plot hole. If the Catalyst could fuse organics and synthetics in order to keep them from killing each other, why not do that in the first place?! Why bother with the Reapers at all if you've already got a full-proof, peaceful solution that doesn't involve slaughtering trillions?
Sure, you need a high war-readiness and presumable the Crucible has to be really well-built to pull it off, but if you've got the capacity to build Reapers in the first place, whipping up a Synthesis-quality Crucible shouldn't be a problem.