Can I just say something about the Fallout things mentioned here, thus far? Okay, yeah, Cazadors are annoying pains in the ass, too which I'll add Giant Radscorpions because I'll get a ton of them at one time. But Deathclaws and Enclave soldiers? That doesn't fit my definition of obnoxious.
First of all, Deathclaws are fucking scary. They are your Holy Shit enemy, the monsters of the series. Not some giant bug creature, but an evolved predator which understands its role in the universe...to be badass. Meeting them early on IS bad, but that's just the luck of the dice. They're suppose to still be bad at level 30, so don't feel bad.
Second, the Enclave are not obnoxious for being in groups, using some tactics, and having high-tech stuff on their side. Powersuits and plasma rifles has been their shtick from day one and that's pretty hardcore. But them staying in groups and moving around as a well-trained unit is par for the course. They're the U.S. military. It makes sense in context.