The final boss of Fallout 2. Why? Because I spent most of my upgrade points on my persuasion skills and when faced with a big ass super mutant in power armor with 999 health I was pretty much screwed even though I had a squad of Enclave troops halping me out. Plus my game glitched so I couldn't get those stupid turrets to stop shooting at me. I beat him eventually thanks to a high powered shot between the eyes, but almost all of the troops who were helping me were already dead.