Haven't read any comics in several years, but I was a hardcore follower of Fables when it started. Great stuff, and some really compelling stories. I've tried to keep a pretty close eye on Bill Willingham ever since I read The Elementals (Comico, 1984-1996). It had its issues (no pun intended) but it was a pretty fun read.
I also have to agree with the people who've brought up Transmetropolitan and the IDW Transformers titles. Both superb imo.
And The Boys was just in a class by itself to me.