As with any comedy, it's always much funnier if it's true. I take his reviews just as seriously as I would take any other review - that is to say, take the review in context of the information one has about the thing being reviewed. Yes, most of his complaints amount to nitpicking, but really, it's often the buildup of a lot of small faults that will ruin a game one might have liked otherwise. In fact, we can often ignore bigger flaws when we like the little details. Like the Fallout games: incredibly buggy, crash often, but they're great when they do work because of the attention to detail.
So, if he's reviewing a game you think you might like, obviously you have to decide whether the flaws he points out would bother you. If not, buy it. If so, don't buy it. It's pretty simple. Collect as much information as you can from as many sources as you can, and make your purchasing decision.