Voted Nay, watching a Family Guy episode (especially a newer one) really just feels like watching Seth MacFarlane masturbate for twenty minutes. It's just so charged with his own self-indulgent personal philosophies, and even if I agree with him philosophically it feels so dirty, he doesn't represent his opposition well at all. It amounts to a debate where one side gets up and says, "My opponent is a DOODY HEAD HAHA HAHA"
I don't even have a problem with crassness or low-brow humor. I'll laugh at anything, as long as it's clever. That said, Family Guy relies way too often on that thing where it's basically just filler - i.e. the infamous "MOM MOM MOMMY" bit or when Peter bashes his knee and sits there for upwards of a full minute and a half just rocking back and forth cradling it. How is that at all funny? The first time I saw a gag like that I was like "roflol hehe" but it loses its humor value pretty quickly.
I won't say it's garbage though, it's done plenty of really clever jokes/episodes. And Adam West is always awesome. But especially when Seth made American Dad and that series with Cleveland and both of them had pretty much exactly the same basic structure as Family Guy... I dunno, I've grown very weary of Seth MacFarlane in general.