I've been fighting depression for about 15 years now. It's odd. Some days I can be fine, then a day later I'm considering stepping out in front of a train. The smallest thing can throw me off completely. I tried anti-depressants (SSRI's and old-fashioned tricyclics), but all they did was make me fidget and belch. I didn't feel like myself.
Big problems don't hit me as hard, I seem to rise to the challenge. It's a culmination of small things that'll do me. It's hard to explain, but if I were to try, I'd say "I'd rather be punched hard in the face once, than be hit with a spoon all day, every day".
Worries about finding a job recently have led to severe anxiety issues too. I don't eat regularly, my stomach is knotted up with worry, and I can't even sleep due to a really weird feeling that spreads all the way down into my legs!
I'm on a short fuse at the moment.