1st - Activision in first for being the most money-grabbing whores in the industry, churning crap out on a production line with little to no innovation or creativity. CoD's success has changed gaming as a whole for the worse.
2nd - EA in a near second for a) buying BioWare who up till then could do their own thing free of EA interference and tactics, b) closing down more decent studios than I can remember (Westwood, dice, Pandemic), c) churning out the annual sports franchises and getting away with it for decades and d) all the crap and controversy around Origin and pulling games from Steam. Not cool you sneaky, underhanded gits.
3rd - Nintendo for not creating an original game in decades and for turning gaming into a casual, hand waving fiasco that has developers diverting resources to creating pap like Cooking Mama instead of actual good games.
4th - Ubisoft for draconian DRM and their apparent attitude towards PC development.
I have nothing but love for BioWare, Bethesda, Capcom, 2K and Atari.
Oh, and Microsoft and Sony get honourable mentions for keeping hardware development back for so long. We're at least a year or two overdue for a new console generation.