I think the fact that there is a non-secret Achievement, or even an achievement at all, for doing all of them ruins the weight of the endings, as in the end I just saved beforehand and plan on doing them all to get 50g.
However, if I could only make one choice for the whole game, I'd choose Sarif's.
Augmentation technology is here, it's here to stay, you can't reverse it's existence as much as Darrow wanted to, and you can't regulate it too heavily as Taggart wanted to, so logical option for me was to calm fear and proceed into the inevitable new age of Augmentation.
However, I agreed with Taggart that regulation should exist, to some extent, in the same way gun laws are regulated, but only for the potentially dangerous Augs.
Things like increased strength/speed/etc shouldn't be regulated, as there are exeptionally strong/quick normal humans too, that's like saying the average man can go to the gym, but he can't have too much muscle. Ridiculous.
I did love the ending, I was wondering how Adam would end up affecting the entire human race, and it kept me guessing and was satisfying.
Final boss fights were shit, though.
Took out Namir with 3 Grenade Launcher shots...
They should've been more than just 'Shoot repeatedly in any way possible until dead'; like you should've had to figure out one of a few specific ways to kill them, for example luring the boss into an electrical field and then short-circuiting them.
Apart from the girl, they were just 'Use explosives at start'.
Still sucks that you couldn't either talk them out of violence or avoid them altogether, as is the style with the rest of the game.