A bit of an odd choice, but I prefer ballistic weapons. Grenade launchers, in particular, but I'll even take mortars and other stuff on occasion. Once I've had a chance to get used to the weapon, I actually find it much easier to guestimate a trajectory and let the explosive do the work than to try and follow a target with a point-and-click weapon, especially if the target is moving quickly. Give me a pistol or other light weapon for when my ammo inevitably runs out, and I'm a happy camper.