Looks very interesting. It's up there with Fallout: New Vegas, Mario Galaxy 2 and Portal 2 as one of the games I'm most excited for this year.
Never played Red Dead Revolver, but then again it doesn't look like I need to. Even if the two games are connected the pieces of the puzzle are all present in this game anyway; Dude was a bad guy, dude gets wife and goes good, dudes wife is captured and he must hunt down old mate, shit goes down.
I really need to watch some old westerns in preparation.