I...um, there's something seriously wrong with this poll.
Half of those aren't "pop culture franchises". Not even close.
Take a look at the Lego franchises thus far: Star Wars, Batman, Indiana Jones, Harry Potter. All are recognizable by almost anyone in the country. I could mention any of those to my grandma, and she would know what I'm talking about.
Starcraft? Wheel of Time? Discworld? The vast majority of the country has no idea what those are. And as far as Twilight and Jersey Shore go, they are pop culture icons indeed, but there's no way they could conceivably translate well to a game.
That being said, I'm going to go ahead and suggest Lego Matrix. I think that would be a pretty neat idea.