I have high hopes for GTAV...
#1 - Let me turn the cell phone off, or better yet - let me throw it down the street. The constant friend calls were really annoying IMO.
#2 - Bicycles. The bikes, esp the dirt bike are great fun, but I missed cycling and there's something quite cool about evading the cops on a BMX.
#3 - Character customisation.
#4 - Aircraft. Ok I might suck at flying, but the option would be nice, and would allow for some great stunts.
In fact, all I need from GTAV, is GTA:SA

- it just seemed like my ideal sandbox game from start to finish.