You know, after thinking about it a bit, Dane Cook would probably make a better Deadpool than Ryan Reynolds. I mean, don't get me wrong, I think Reynolds is a better actor hands down, but he always plays his characters more...how can I put this...'smartassedly' crazy, whereas Dane Cook's characters are usually more 'dickishly' crazy, and Deadpool's always struck me as being more, well, being more of a straight up jerk than being just smartalec-y.
Anyway, I always though that Cillian Murphy would make a pretty awesome Carnage, which is more supervillian, but yeah.