I've seen too many episodes of Family Guy and I won't be sad if I never see one again. I find its humour to be thorougly cheap and shallow. First, the animation is very bland. Secondly, The voice acting is boring at best and grating at worst. And third, most if its jokes are simply references for their own sake, and the few jokes with potential are dragged on to a bore. To me, it's just afwul television, just like its carbon-copies American Dad and Cleveland Show.
So yeah, I hate the show. I know a lot of people who really seem to enjoy this stuff though, and my friends throw a lot of FM-references around. The times I had to sit through a "humourous" rendition of "the bird is the world" are noumerous. They never go on about the appeal of Brian's cool live-in uncle appeal or anything like that, and the show really doesn't seem to bother with any kind of characterization beyond what's neccesary for cheap jokes.
Once again, I think Bob's reading too much into things. MacFarlane seems like an okay guy and does posses some talents, but as I see it, he had an unexpected hit with an easy Simpsons knock-off and hasn't really had the guts to try anything radically different since then.