Well. For starters.
"Yay! Fucked-up imagery!"
I hope for lots of running. I would like a Fallout/Elder Scrolls style RPG where it's heavily based around survival. Where you have to sneak in, grab the goods, stun the scaries and run for your life. Rarely killing anything. I love customisation, so that's basically all I could ask for when it comes to this game being an RPG. It's unlikely that it will fulfil my desires but Bethesda's good at RPGs. I like to see them do RPG things, but to put a different spin on 'em each time. Eh, I doubt many will agree.
People have worded this as "Bethesda's new game", fooling me into thinking Bethesda wasn't just publishing this time. Damn. How foolish of me. Still, looks incredible.
I loved how the trailer lures you into a false sense of security. Every time I rewatch it I don't want to the music to stop, and welcome it back at the end.
This is REALLY UNLIKELY, but I get the idea spider-arm-girl is an ally. Why else would a guy be messing with barbed wire potentially making himself BLEED if he didn't want her to come help fight Safe-face? I dunno, I'm just speculatin'.