Age of Empires 3. Definitely DA 2, not because they changed combat mechanics and such, I actually liked that. Because of the cluster**** way it through enemies at you basically ignoring logical thinking or the positioning and strategic emphasis the first one had. In my opinion I always thought DA:O could use a bit more urgency when it came to combat. Maybe not the breakneck speed that DA2 brought.
I also couldn't stand GTA4, and by the extension RDR, because almost everything about the game was just boring; RDR even more so. Not even the online could distract me enough, and I find it ridiculous that I had more fun simply running around with friends on online than trying to do anything alone, even acting like a normal ped was more entertaining with friends than going on rampages in GTA4 and RDR; and usually the point of the GTA series was to be a giant sandbox where you can have fun.
MGS4, after playing and loving every second MGS2 and MGS3 (guess worth noting that I started on MGS2, so I didn't have a man crush on Snake, yet.) MGS4 just came off as a collaborative effort to do way too much fan-service. Not to say I didn't have fun, but in every other installment, even the when I played the remake of the first one, I watched all cutscenes. I skipping a majority of the ones in MGS4 because they took an overly dramatic long amount of time to explain twists and curves of a story that, I felt, kinda fell apart at the start. Even worse, I was almost moved to tears with Snake killing himself to save the world, it gave him a messiah feeling to me, only to find out that he didn't and Big Boss appeared out of nowhere to explain the stuff I didn't exactly care about. I would've much Snake been the hero the world needed, but would never know about; like The Boss.
MK9, not to say I played much of the old games. The reworking of the game is actually incredibly good, and for a while, I really enjoyed it. But the online community ruins the game, most of them can't play and spam the overpowered characters and moves, and I guess it stems from how MK9's combat is. The combat isn't as focused on combos as the first, and only, fighting series I'm used is. (Blazblue) and is more focused on simply using the specials at your disposal to counter your opponent, especially because the lightning fast X-Ray attacks (where as in Blazblue, I feel it's more balanced because the game freezes the frame for the attack start up, but it doesn't actually cause the game to move, so it can only be used to punish actual mistakes, not a human's ability to react.)
And I guess I just wrote an essay on sequels, and I'm probably not close to all the ones I can think of.