Kingdom Hearts and Mass Effect.
One is a crossover between Disney and Square Enix, with swords shaped like keys, anime hair, magic powers, and the power of Friendship personified. Most ladies are princesses, most guys are either moody or upbeat, and the non-human characters include dogs, ducks, and mice.
The other one is a completely original setting that harkens back to the age of space operas, with third person shooter gameplay, combat armor with shields, telekinetic powers granted by rocks in the nervous system, and a realistic and believable setting. Most ladies are capable of kicking ass, most guys are capable of kicking slightly less ass, and the non-human characters include at least a dozen different species of wholly unique and recognizable aliens.
Try and guess which is which.