Personally, I don't give a damm who's playing Nathan Drake (it could be Whoopi Goldberg for all I care); I'm just really happy that David O'Russell is set to direct this movie.
For those of you who aren't film fans, let me put it this way: if David O'Russell truly does direct, this will be the first time in movie history, that a video game movie is directed by a REALLY REALLY GOOD director. So far, the best director to have directed a video game movie has Mike Newell, and he hasn't made a great movie in years.
In other words, this is the first video game movie we should actually be anticipating!