Ever since I figured out how to reliably unlock the Tainted characters in Isaac, I've been working my way through the game with them. They're very fun, each having their own gameplay twist to make them unique. I already completed all marks with Tainted Lilith, Isaac and Samson, only 1 left to complete with Apollyon, and I managed to complete 7 out of the 12 completion marks on my very first run with Tainted Azazel. I lucked out and got Hemolacria as my first treasure room item. While it's not an autowin button, it's still an immensely powerful item, and more importantly, overrides Tainted Azazel's gimmick entirely, allowing me to play the game normally.
It's honestly staggering how such a simple game can have so much variety and stay fresh for so long well after 700 hours and nearly 10 years. But it's actually very simple: as you play it more and more, you constantly unlock new things, items, gameplay mechanics etc.
It's honestly staggering how such a simple game can have so much variety and stay fresh for so long well after 700 hours and nearly 10 years. But it's actually very simple: as you play it more and more, you constantly unlock new things, items, gameplay mechanics etc.