I've beaten Kaycee's Mod in Inscryption with every starter deck (but one, more on that) and as far as I'm concerned you might as well scrub anything that isn't the Black Goat deck or the Mantis God deck ASAP. The worst offender is the Mysterious Egg deck, which starts you with three bunk cards and zero damage output. What the deck wants you to do is amass a veritable menagerie of cards representing at least 1, 2, 3, 4 and 5 attack points, 1, 2, 3, 4 and 5 health points, and cutting across all 5 types (avian, reptile, canine, cervid and insect). And THEN each egg will hatch into an absurdly overpowered hydra. But if you somehow made it so far into a run to manage to collect all that shit, you're probably not hurting for hydras.
Inevitably I end up furnacing all this extraneous stuff just to replicate the same deck every run, decks & RNG notwithstanding: whittle down every deck to a single low cost card (which is forced into every first draw) that is either a Black Goat with an unkillable sigil that lets me play an OP card, or a buffed the fuck up Mantis with double base damage. There's a gimmick to every boss that can be worked around with specific items, but that's pretty much it. If you can make it past the first map you're probably good for the rest of the run.
Currently parked in front of the final boss, with the final deck I need for Plat. But I'll leave it at that and go play something else to farm the other 158 trophies I need to match Inscryption's Plat to my 9,000th overall, because I like it when the milestone pics on PSN Profiles match games that I really like.