Call of Cthulhu: Dark Corners of the Earth.
Early in the game, the part which is based on The Dunwhich Horror, there's a part where you have to barricade yourself in your hotel room & escape.
Just the sheer terror of having to screw the lock to the door, push shelves in front of the door, make your escape was too much for me & I could only attempt that level a few times in a row before I had to play another game!
It's a very scary scenario from the master of horror, which was actually enhanced by being a level in a video game, since unlike the book, you could die & were entirely responsible for the fate of your character. No other game has conveyed the sense of panic & terror that I got from playing that game.