Backstory of friend: Hardcore gamer, one of "those guys", but also liked to pretend he could snowboard. Results: Broken arm 4 years IN A ROW. Year 2: Broke wrist, but when it was cast, it wasn't cast very well, leaving his thumb tendon rubbing against broken bone for 2 months.
Day cast came off: Went home and celebrated by playing some Smash Brothers on GameCube. Halfway through match... thumb tendon snaps. Friend looks down and says "hur hur thumb doesn't work anymore". Picks thumb up with other hand, places it back on joystick, and disappointingly, finishes 2nd. Surgery time: tendon retracted too far up arm, need to replace with part of tendon from pointer finger. Then, cast up REAL good. This is when he learned to play Smash with his palm.
Unfortunately, this isn't me, just a friend. Worst I can say is a low blow playing Wii Boxing, or the typical dizziness/nausea from Wolfenstein.