Marvel vs Capcom 3 -- unless the market falls out for fighting games, I figure it's pretty safe
Mortal Kombat -- ditto
Elder Scrolls V -- popular RPG franchise, it's a hit
Bulletstorm -- could easily under-perform, but I think the advance buzz from the demo indicates otherwise
Zelda -- core Nintendo franchise, don't see it faltering now
Dragon Age 2 -- popular RPG franchise, success
Uncharted 3 -- don't know if it can surpass the second one, but it's a pretty safe bet it'll be a hit
Gears 3 -- ditto
Duke Nukem Forever -- can't hazard a guess until we see a demo. If the game is any kind of quality, it'll do well
Mass Effect 3 -- see Gears & Uncharted... also popular RPG franchise, safe as houses
L.A. Noire -- best guess is it's a hit because it's from Rockstar, but it's a new IP, so anything can happen
Batman Arkham City -- should be successful. Too much Bat history for the last game to be a fluke.
The Last Guardian -- know nothing about this one.
Deus Ex -- I'm hopeful and it's certainly got a lot of eyes on it. But it's an IP with no recent history and a fanbase that is going to be hyper critical.
Crysis 2 -- probably a solid seller, but not a break-out hit.
Portal 2 -- this is like a half-hour comedy getting a feature length movie... can they stretch the material to fit a full length game or does the audience start checking its watches half an hour in.
F3AR -- third entry in a popular franchise. Should perform.
Battlefield 3 -- know nothing of the franchise. No guess
Homefront -- this one can go either way. If the single player is up to snuff and it gets good reviews, it should be a solid hit. If the game is a near-miss like Medal Of Honor, it'll probably just do okay. Definitely depends on the reviews.
COD MW3 (Rumor) -- if it comes out, it's a big hit... just like all the others. CoD probably gets one shit entry before audience erosion starts to set in and I don't think Black Ops was that.